Sally the Adventurer


Side effects

Common, rare, and rare side effects of paroxetine include:

From the side of the central nervous system: headache, nervousness, paresthesia, insomnia, drowsiness, emotional lability, asthenia, tremor, convulsions, fatigue, stimulation, depersonalization, memory impairment, depression, hyperkinesia, dizziness, myoclonus, in rare cases extrapyramidal disorders, in particular akathisia , in extremely rare cases of hallucinations .

From the autonomic nervous system: increased sweating, dry mouth .

From the cardiovascular and lymphatic system: in rare cases, hypertension, tachycardia, bradycardia, hematomas, hypotension, orthostatic hypotension, anemia, leukopenia, lymphadenopathy, purpura; increased risk of bleeding, especially when taking aspirin, non-steroidal anti-inflammatory drugs, warfarin and other anticoagulants while taking paroxetine .

From the genital and urinary systems: decreased libido, urination disorders, sexual disorders (including ejaculation disorders and impotence) .

From the digestive system: nausea, decreased appetite, vomiting, constipation, diarrhea, clinically significant weight gain; in rare cases, hepatotoxic effect: increased levels of transaminases, cholestatic and hepatocellular lesions .

From the respiratory system: respiratory disorders, rhinitis, sinusitis.

Other: allergic reactions, chills, swelling of the face, malaise, neck pain, migraine, fainting .

Paroxetine is characterized by an increased suicidal risk in different age categories: young people, adolescents and adults .

In rare cases, paroxetine can induce mania or hypomania in patients with unipolar depressive disorder as well as in patients with bipolar affective disorder.

When using paroxetine, in rare cases, even at a therapeutic dose and most often with the concomitant use of tryptophan, tramadol, triptan, lithium, irreversible MAOI or other serotonergic drugs, the risk of a potentially deadly side effect - serotonin syndrome - is not ruled out.

Possible, especially at the first stage of treatment or when adjusting the dose up or down, anxiety, excitement, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, other unusual changes in the mental state, increased depression or suicidal thoughts .


Paroxetine and other SSRIs are used with caution in patients with epilepsy (careful monitoring is necessary, treatment is stopped when seizures develop), while ECT is used, and in case of cardiovascular diseases. here SSRIs, although only slightly, can affect concentration and coordination - for example, when driving vehicles .


Discontinuation of treatment

As can be seen from the reviews about "Paroxetine", drug withdrawal leads to a deterioration in the state of health, which is manifested by the suffering of the whole organism, to the regular intake of a kind of "doping." Withdrawal syndrome is also characteristic of other drugs that actively affect the human psyche. Among similar medicines, Paroxetine has one of the highest rates..

As a rule, withdrawal syndrome manifests itself in sleep disorders, nightmares and insomnia. A sudden refusal to take the drug provokes nausea, irritability, depression, tearfulness. Other patients noted that they had a headache, worried about anxiety. It is possible to minimize the negative effects, as can be seen from the reviews about Paroxetine, if you stop using the antidepressant gradually, gradually reducing the dosage for some time..