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Amoxicillin vs. Augmentin: Differences and Comparison between Side Effects, Dosage, and Uses
Amoxicillin belongs to a class of antibiotics called penicillins. Other members of this class include ampicillin (Unasyn), piperacillin (Pipracil), ticarcillin (Ticar), and several others. buy augmentin online Amoxicillin is used to treat infections due to bacteria that are susceptible to the effects of amoxicillin. Common bacterial infections that amoxicillin is used for include infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis), lungs (pneumonia), urinary tract, and skin. Amoxicillin also is used to treat gonorrhea.
Augmentin (amoxicillin/clavulanate) is a combination antibiotic used to treat bacterial infections including sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. Amoxicillin belongs to the penicillin drug class.
Pediatric Patients
Based on the amoxicillin component, AUGMENTIN should be dosed as follows:
Neonates and Infants Aged <12 weeks (<3 months): The recommended dose of AUGMENTIN is 30 mg/kg/day divided every 12 hours, based on the amoxicillin component. Experience with the 200 mg/5 mL formulation in this age group is limited, and thus, use of the 125 mg/5 mL oral suspension is recommended.
Patients Aged 12 weeks (3 months) and Older: See dosing regimens provided in Table 1. The every 12 hour regimen is recommended as it is associated with significantly less diarrhea [see Clinical Studies ]. However, the every 12 hour suspension (200 mg/5 mL and 400 mg/5 mL) and chewable tablets (200 mg and 400 mg) contain aspartame and should not be used by phenylketonurics. [see Warnings and Precautions ]
Table 1: Dosing in Patients Aged 12 weeks (3 months) and Older
a Each strength of suspension of AUGMENTIN is available as a chewable tablet for use by older children.
b Duration of therapy studied and recommended for acute otitis media is 10 days.
Patients Weighing 40 kg or More: Pediatric patients weighing 40 kg or more should be dosed according to adult recommendations.
The 250-mg tablet of AUGMENTIN should not be used until the child weighs at least 40 kg,due to the different amoxicillin to clavulanic acid ratios in the 250-mg tablet of AUGMENTIN (250/125) versus the 250-mg chewable tablet of AUGMENTIN (250/62.5).
Patients With Renal Impairment
Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe. Renal impairment patients with a glomerular filtration rate of <30 mL/min should not receive the 875 mg dose. Patients with a glomerular filtration rate of 10 to 30 mL/min should receive 500 mg or 250 mg every 12 hours, depending on the severity of the infection. Patients with a glomerular filtration rate less than 10 mL/min should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection.
Hemodialysis patients should receive 500 mg or 250 mg every 24 hours,depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis.
Augmentin for Pneumonia
First-line antibiotics such as azithromycin or clarithromycin, and broad-spectrum antibiotics such as Augmentin and Amoxicillin, may be selected for the treatment of community-acquired pneumonia.
It is a chemically artificially modified antibiotic. It contains amoxicillin in combination with clavulanic acid. The combination of two active substances expands the spectrum of its effects, enhances the therapeutic effect. Amoxicillin interferes with the growth of a number of bacteria. The acid acts as an auxiliary element and as an antibacterial agent. Its molecule has a similar structure to penicillin and acts on microbes, destroying them. Harmful microorganisms with special sensitivity to the drug:
- streptococcus;
- staphylococcus;
- Pneumococcus;
- meningococcus;
- gonococcus;
- salmonella;
- yersinia;
- klebsiella;
- clostridium;
- gardnerella;
- haemophilus influenzae
Pneumonia is a disease in which the lung tissue becomes inflamed with an infectious agent. This means that it is necessary to treat this disease with antibiotics, as well as other, additional drugs that alleviate the patient's condition and improve the delivery of the antibiotic to the site of inflammation. Treatment should be taken with the utmost seriousness. So, the first aid for pneumonia is an antibiotic. This group includes a drug such as Augmentin.
A variety of microorganisms can cause pneumonia. In most cases, these are bacteria (then pneumonia is called bacterial), but sometimes viruses and fungi are the cause. It is difficult to determine the exact type of microbe: microbiological examination of sputum is necessary, which is not done in all hospitals. Antibiotics of a wide spectrum of action come to the rescue, which can act on many different bacteria, and, accordingly, are more likely to be able to help a particular patient.
Amoxicillin and clavulanic acid, which are part of the composition, penetrate into the lung and destroy bacterial cells (destroying their walls). This type of treatment is called etiotropic - affecting the root cause. Augmentin also treats infections of the ear, throat, nose, urinary tract, sepsis, and other bacterial infections.
Inflammation of the lungs in the absence of treatment threatens a person with death, since there is no chronic form of it. Until people knew about the existence of antibiotics, pneumonia took many lives. But thanks to antibacterial agents in our time, it is possible to cure almost all types of pneumonia and in most cases to avoid any complications. From pneumonia, Augmentin can be drunk by both adults and children.
Bacteria that can provoke an inflammatory process in the tissues of the lungs in most cases enter the human body by airborne droplets, sometimes through the blood. It should be noted that pneumonia rarely appears on its own: it usually occurs as a complication in the chain of respiratory diseases or develops against the background of a weakened immunity or general weakness of the body caused by other diseases.
Sally the Adventurer
Side effects
Common, rare, and rare side effects of paroxetine include:
From the side of the central nervous system: headache, nervousness, paresthesia, insomnia, drowsiness, emotional lability, asthenia, tremor, convulsions, fatigue, stimulation, depersonalization, memory impairment, depression, hyperkinesia, dizziness, myoclonus, in rare cases extrapyramidal disorders, in particular akathisia , in extremely rare cases of hallucinations .
From the autonomic nervous system: increased sweating, dry mouth .
From the cardiovascular and lymphatic system: in rare cases, hypertension, tachycardia, bradycardia, hematomas, hypotension, orthostatic hypotension, anemia, leukopenia, lymphadenopathy, purpura; increased risk of bleeding, especially when taking aspirin, non-steroidal anti-inflammatory drugs, warfarin and other anticoagulants while taking paroxetine .
From the genital and urinary systems: decreased libido, urination disorders, sexual disorders (including ejaculation disorders and impotence) .
From the digestive system: nausea, decreased appetite, vomiting, constipation, diarrhea, clinically significant weight gain; in rare cases, hepatotoxic effect: increased levels of transaminases, cholestatic and hepatocellular lesions .
From the respiratory system: respiratory disorders, rhinitis, sinusitis.
Other: allergic reactions, chills, swelling of the face, malaise, neck pain, migraine, fainting .
Paroxetine is characterized by an increased suicidal risk in different age categories: young people, adolescents and adults .
In rare cases, paroxetine can induce mania or hypomania in patients with unipolar depressive disorder as well as in patients with bipolar affective disorder.
When using paroxetine, in rare cases, even at a therapeutic dose and most often with the concomitant use of tryptophan, tramadol, triptan, lithium, irreversible MAOI or other serotonergic drugs, the risk of a potentially deadly side effect - serotonin syndrome - is not ruled out.
Possible, especially at the first stage of treatment or when adjusting the dose up or down, anxiety, excitement, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, other unusual changes in the mental state, increased depression or suicidal thoughts .
Precautions
Paroxetine and other SSRIs are used with caution in patients with epilepsy (careful monitoring is necessary, treatment is stopped when seizures develop), while ECT is used, and in case of cardiovascular diseases. here SSRIs, although only slightly, can affect concentration and coordination - for example, when driving vehicles .
Discontinuation of treatment
As can be seen from the reviews about "Paroxetine", drug withdrawal leads to a deterioration in the state of health, which is manifested by the suffering of the whole organism, to the regular intake of a kind of "doping." Withdrawal syndrome is also characteristic of other drugs that actively affect the human psyche. http://www.rxlist.com/consumer_paroxetine_paxil_brisdelle/drugs-condition.htm Among similar medicines, Paroxetine has one of the highest rates..
As a rule, withdrawal syndrome manifests itself in sleep disorders, nightmares and insomnia. A sudden refusal to take the drug provokes nausea, irritability, depression, tearfulness. Other patients noted that they had a headache, worried about anxiety. It is possible to minimize the negative effects, as can be seen from the reviews about Paroxetine, if you stop using the antidepressant gradually, gradually reducing the dosage for some time..
